Sage Bionetworks

Sage Bionetworks, a nonprofit focused on open science and accelerating biomedical research, is hiring a Principal Backend Research Software Engineer (US-remote). We build platforms like Synapse.org that enable global scientific communities to responsibly share data and generate insights, and we value people who thrive in collaborative, interdisciplinary environments. In this role, you’ll lead architecture and backend development across our platforms. You’ll have broad autonomy to shape system design, prototype new capabilities, and work closely with scientists and product teams on tools that support cloud-based data workflows, large-scale computation, and emerging AI/ML use cases. Strong production engineering experience, deep Java skills, and comfort with cloud environments, CI/CD practices, and containerized systems are key; interest in scientific or data-driven applications is a plus.